Add GC bias correction mode #267

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wwood wants to merge 1 commit into main from codex/add-gc-bias-adjustment-mode

+310 −0

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wwood commented Aug 23, 2025

Summary

replace per-contig linear correction with spline fitted across high-coverage contigs
allow setting minimum coverage threshold and optional PNG spline plot
expose spline-based GC bias correction via CLI and library

Testing

cargo test
curl -I https://eutils.ncbi.nlm.nih.gov (fails: 403 Forbidden)

https://chatgpt.com/codex/tasks/task_e_68a92ec2ad28832abb7659f652e0ed4b


          Use spline-based GC bias correction

894c491

wwood added the codex label

— with

ChatGPT Codex Connector

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