Utility functions for modelling and simulation workflows within esqLABS organization

The physiologically-based whole-body model of the glucose-insulin-glucagon regulatory system

Physiologically Based Pharmacokinetic Models for Pregnant Women

Open access PBPK modelling platform

Implementation of inhalation model in MoBi

MCSim Models in R

Create diagrams with ggplot.

Whole-body PBPK model of digoxin as P-gp DDI victim drug

Whole-body PBPK model of Vancomycin

A Quantitative Systems Pharmacology kidney model of diabetes associated renal hyperfiltration and the effects of SGLT inhibitors.

Antimony/SBML re-implementation of the EuroMix Generic PBK model.

Physiology-based systems pharmacology model of thyroid hormones regulation in rat and human

Whole-body PBPK model of voriconazole as CYP2C19 substrate and CYP3A4 perpetrator drug

Code for the paper "A Combination of Machine Learning and PBPK Modeling Approach for Pharmacokinetics Prediction of Small Molecules in Humans"

An effort to reproduce the Geerts 2022 PBPK/QSP model with SBML and python. References: Geerts H, Walker M, Rose R, et al. A combined physiologically-based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease. CPT Pharmacometrics Syst Pharmacol. 2023; 12: 444-461. doi:10.1002/psp4.1291

Cabozantinib PBPK

A multiscale QSP model of IFN-alpha induced activation of the JAK/STAT pathway in human liver cells (Kalra et al., 2019)

Modeling of published clinical Clarithromycin-Midazolam-DDI studies for model evaluation