HPOA Builder

An interactive Streamlit app for browsing diseases, editing HPO annotations, and extending them with LLM-based PubMed suggestions. This is designed for curators who need a clean workflow for validating Human Phenotype Ontology Annotation (HPOA) tables.

Features

• Search and filter diseases: Quickly find diseases using multiselect or search.
• Inline editing: Select diseases and edit their annotations directly in a spreadsheet-like table with no need to touch the original dataframe.
• Session-safe copy: All edits are saved to a copied dataframe, so your master data remains untouched.
• PubMed + LLM Agent: Coming soon, with help from Aurelian.
• Monarch-style UI: Custom colors and UI elements styled to match the Monarch Initiative.

Quick Start

Clone and install:

git clone https://github.com/blakebyer/hpoa_builder.git
cd src/
pip install requirements.txt

Run the app:

streamlit run app.py

Screenshot