ASE Data from Reference Cohorts

Allele-Specifc Expression Data From Reference Cohorts Following Best Practices

Data Repository

MAGE_ASE.tar.xz

Contains Data from the MAGE study spanning 731 individuals from 26 different ancestry groups. Briefly allele-specific expression data (ASE) was generated using high coverage 1000 genomes genotypes and phASER using best practices. The following archive should contain two CSV files namely:

• MAGE_ASE/MAGE_varlevel.csv: Containing ASE data aggregated at variant level by choosing the most expressed SNP overlapping each gene (as defined in gencode v26). Variant level ASE was produced from the allelic_counts file from phASER.
• MAGE_ASE/MAGE_haplevel.csv: Containing ASE data aggregated at haplotype level using phASER and gencode v26.
• Both files have the same input structure with rows being Genes (identified by ENSEMBL IDs) and columns being the Sample IDs. The values are pairs of (reference, alternate) counts.
• Application of ASE Quality Control on the Cohort can be retrieved from our paper here