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Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome

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Release BioConda Preprint

Introduction

Longdust identifies long highly repetitive STRs, VNTRs, satellite DNA and other low-complexity regions (LCRs) in a genome. It is motivated by and follows a similar rationale to SDUST. Unlike SDUST which is limited to short windows, longdust can find centromeric satellite and VNTRs with long repeat units.

Longdust also overlaps with tandem repeat finders (e.g. TRF, TANTAN and ULTRA) in functionality. Nonetheless, it is not tuned for tandem repeats with two or three copies, but may report low-complexity regions without clear tandem structure. Longdust complements TRF etc to some extent.

You can find the algorithm and comparison to other tools in the following preprint:

Li H and Li B (2025) Finding low-complexity DNA sequences with longdust. arXiv:2509.07357

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Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome

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